IL1B and obesity due to melanocortin 4 receptor deficiency: For example, obesity [45], inflammaging [46,47], cardiovascular disease [48], hypertension [49,50], and rheumatoid arthritis [51,52] are characterized by elevated concentrations of circulating cytokines, such as IL-1b, IL-6, IL-8, IL-10, IL-13, TNF-α, and IFN-γ.