MGMT and glioblastoma: Given the heterogeneous expression of the DNA repair protein MGMT in GBM, verifying if the combination of CUR+PLD could be of benefit independent from the methylation levels of the MGMT gene promoter and, consequently, from the sensitivity to TMZ, we used, as cellular models of glioblastoma, the cell lines U87 and LN18, which are negative and positive for MGMT expression, respectively (Figure 1b).