TGFB1 and breast cancer: Hallmark GSEA indicated that MHC-I signature score in breast cancer samples from the TCGA database was markedly positively correlated with immune pathways, including interferon α/γ response (Figure 1D,E), while negatively correlated with procancerous pathways, such as estrogen response early and TGF-β signaling (Figure 1D,E), which indicates that targeting these pathways would be sufficient to enhance MHC-I expression in breast cancer.