Although fewer in number, some studies proved that circulating MMP-1, MMP-2, and MMP-9 present similar augmentation in thoracic aortic aneurysms, aortic dissection, can predict the necessity of surgery in subjects with aneurisms of the ascending aorta, and are even correlated with ultrasound parameters such as WSS and time-average WSS (TAWSS) [27,46,47]. This evidence concerns the gene MMP1 and thoracic aortic aneurysm.