Although fewer in number, some studies proved that circulating MMP-1, MMP-2, and MMP-9 present similar augmentation in thoracic aortic aneurysms, aortic dissection, can predict the necessity of surgery in subjects with aneurisms of the ascending aorta, and are even correlated with ultrasound parameters such as WSS and time-average WSS (TAWSS) [27,46,47]. The gene discussed is MMP9; the disease is thoracic aortic aneurysm.