ACHE and neurodegenerative disease: Notably, acorn polyphenols significantly inhibit the expression levels of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in human neuroblastoma cells (SH-SY5Y), indicating their neuroprotective potential for alleviating symptoms associated with Alzheimer’s disease and other neurodegenerative diseases [6].