Our results not only show an improvement in cognitive functions of Sip1wt/fl mice after epilepsy but also in a number of behavioral tests; BDNF overexpression contributed to the improvement of these parameters in Sip1wt/fl mice before pilocarpine injections, which indicates the ability of BDNF to improve the neurological status of mice with genetic defects of the cerebral cortex. This evidence concerns the gene BDNF and epilepsy.