BDNF and epilepsy: Under epileptiform activity induced by pilocarpine injections, 100% of Sip1wt/fl mice with BDNF overexpression survive, whereas more than 50% of Sip1wt/fl mice without AAV-BDNF transduction die within 1 h after pilocarpine injection, which demonstrates a reliable neuroprotective effect of BDNF in epilepsy in vivo.