IFNG and macrophage activation syndrome: The levels of laboratory markers, such as C-reactive protein (CRP) and ferritin, are significantly elevated, in addition to elevated cytokine levels, similar to those observed in hemophagocytichistiocytosis (HLH) and macrophage activation syndrome (MAS), including IL-6, IFN-γ, IL-10, soluble interleukin-2 receptor, MCP-1, and MIP1B [92].