The LRH-1/PTGS2/PGE2/PTGER1 signaling axis is a key pathway mediating the survival properties of BL001, and the expression of PTGS2 is a key target for the activation of this pathway, which may be conveyed in part through immune cell signaling between pancreatic islet cells to convey the reversal of type 1 diabetes symptoms [37]. The gene discussed is PTGS2; the disease is type 1 diabetes mellitus.