CASP3 and type 2 diabetes mellitus: Interestingly, the CTD network of ATK1, PRKCA, CASP3, MAPK1, PTGS1, MMP9, PTGS2 and TNF showed more relevance, and all of these relevant targets have known studies on diabetes through a literature collection review, predicting that the six main components of GE may also treat T2DM by acting on these pathways.