In the meantime, the PI3K/Akt signaling pathway regulates the PRKCA and TNF-α proteins, which can reduce the production of inflammatory factors and decrease pancreatic islet β-cell apoptosis through the downregulation of the expression of pancreatic islet β-cells and the regulation of the disorders of lipid metabolism and then achieve the treatment purpose of T2DM [35]. This evidence concerns the gene AKT1 and type 2 diabetes mellitus.