Aminoacyl tRNA synthetase complex interacting multifunctional protein 1 (AIMP1) and cornichon family AMPA receptor auxiliary protein 4 (CNIH4) are significantly upregulated in HNSCC, in which AIMP1 expression levels are negatively correlated with immunity scores and microenvironment scores, and CNIH4 may affect the level of immune cell infiltration within the microenvironment and cancer immunotherapy [96,97]. Here, AIMP1 is linked to head and neck squamous cell carcinoma.