As the main cell subset of tumor-infiltrating TAMs, M2-like TAMs are activated by IL-4, IL-6, and IL-13 and express immunosuppressive cytokines such as TGF-β, IL-4, IL-10, IL-13, and IL-1 receptor antagonists, which mainly induce and participate in the Th2 immune response and are protumor immune cells [76,77,78]. This evidence concerns the gene IL4 and neoplasm.