FMR1 and fragile X syndrome: Mutant Fmr1 KO mice and rats were generated and displayed altered social interaction and social play behavior, social anxiety, defects in visual attention and auditory dysfunctions, cognitive deficits, repetitive behaviors, and hyperactivity mimicking FXS in humans demonstrating the phenotypic (face) validity with ASD [106,107,109] and were wildly reviewed [111,153].