SHANK3 and autism: Treatment with UNC0642 (1 mg/kg, i.p., once daily for 3 days), a selective and brain-permeable inhibitor of EHMT1 and EHMT2, reduced the elevated level of H3K9me2 in the PFC of Shank3+/ΔC mice and rescues autism-like social deficits and restores NMDAR function in Shank3-deficient mice similarly to above-described studies [118].