Shank3B−/− mice exhibited a more pronounced ASD-like phenotype, than Shank3A-/- mice:anxiety-like behavior, repetitive self-injurious grooming.Shank3B−/− mice demonstrated impaired social interaction preference for social novelty.Shank3A−/− mice preserved normal social communication, deficit for social novelty recognition, striatal hypertrophy, increased neuronal complexity, and dendritic arbors.Reduced frequency mEPSCs in striatal medium spiny neurons.Reduced protein levels of glutamate receptor subunits GluR2, NR2A, and NR2B. This evidence concerns the gene GRIN2B and Anxiety.