INS and Hypoglycemia: Even if the risk of hypoglycemia is lower after the administration of insulin intransally, compared with subcutaneous administration [32], there were some reported side effects during the clinical trials, such as flu-like symptoms, falls, hypoglycemia, dizziness, diarrhea [33], a slow decrease in blood glucose, nasal burning sensation [34], local nasal rhinitis [35], transient nasal stinging, nasal irritation, and unpleasant odor [36].