The frequency of EDA variants in permanent tooth agenesis is 5.9% [16], significantly lower than that in deciduous tooth agenesis (86.9%) reported in the present study, whereas WNT10A is the major pathogenic gene for permanent tooth agenesis, with its variants taking part in 26.0% of permanent tooth agenesis cases [16]. The gene discussed is WNT10A; the disease is tooth agenesis.