AKT1 and metabolic dysfunction-associated steatotic liver disease: Subpopulations of TCRαβ+ and TCRγδ+ double negative cells perform largely antagonistic functions in inflammation processes, so it is interesting to note that arachidonic (cis,cis,cis,cis-5,8,11,14-eicosatetraenoic, 20:4(n-6)) and adrenic (cis,cis,cis,cis-7,10,13,16-docosatetraenoic 22:4(n-6)) acids induced apoptosis of TCRαβ+ DNT cells and decreased their immunosuppressive function, which were mainly associated with the AKT signaling pathway during nonalcoholic fatty liver disease development [111].