Pro-inflammatory factors such as IL-5, IL-13, TNF-α, and IL-6 play a leading role in the pathogenesis of allergic asthma, including the growth of eosinophils, the isotypic transition of B cells to IgE production, chemotaxis of neutrophils, and bronchial contraction [51,52,53]. Here, IGHE is linked to allergic asthma.