An analysis of transcriptomes from 982 acute myeloid leukemia patients showed that RNA variants in isocitrate dehydrogenase (NADP(+)) 2 (IDH2) and serine- and arginine-rich splicing factor 2 (SRSF2) promoted leukemogenesis and epigenome and RNA splicing [32]. The gene discussed is IDH2; the disease is acute myeloid leukemia.