When supplemented in a mixture with propionate and butyrate, it was observed to reduce liver damage in a model of non-alcoholic steatohepatitis (NASH) as measured by decreased circulating levels of the transaminases aspartate aminotransferase (AST) and alanine aminotransferase (ALT), as well as decreased hepatic macrophage infiltration [41]. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.