To investigate the biodistribution and tumor-homing capabilities of iMSCs, we established a xenograft tumor model in highly immunodeficient mice (NOD/ShiLtJGpt-Prkdcem26Cd52Il2rgem26Cd22/Gpt, NCG) using the A549 lung cancer cell line, with tumors implanted subcutaneously in the right flank. Here, GPT is linked to neoplasm.