Duksal et al. examined 144 subjects—50 patients with prediabetes, 50 patients with T2DM, and 44 controls—and reported elevated plasma levels of TNF-α in patients with T2DM compared to the controls and lower levels of IL-10 in patients with T2DM and prediabetes compared to the controls but did not find correlations between these biomarkers and conduction in distal sensory nerves (sural, dorsal plantar, and medial plantar) [105]. This evidence concerns the gene IL10 and prediabetes syndrome.