CAV1 and type 2 diabetes mellitus: A study involving male Sprague Dawley rats with T2DM induced by a high-fat, high-sugar diet for eight weeks followed by an intraperitoneal injection of a low STZ dose showed that CAV1 was persistently upregulated in the spinal cords of rats with diabetic neuropathic damage, concluding that it plays an important role in peripheral neuropathic pain [45].