Apoptosis induction in leukemia cells through USP14 inhibition has been previously documented [37]; however, this is the first study to identify a specific mechanism by which USP14/UCHL5 inhibition induces apoptosis in FLT3-ITD-positive AML cells or in primary FLT3-ITD-positive AML cultures. The gene discussed is UCHL5; the disease is leukemia.