Comparison of whole transcriptome RNAseq analysis showed that CARD11 appears to play a key role in CRC progression through dysregulation of the NF-κB pathway, promoting cell growth and tissue remodeling in the HCT-116 CRC cell line and inducing chemotaxis and ECM organization pathways in the HT-29 CRC cell line. The gene discussed is NFKB1; the disease is colorectal carcinoma.