To gain a better understanding of the role of CARD11 in CRC pathogenesis and, more specifically, how overexpression of CARD11 can affect the downstream signaling pathways in the pathogenesis of CRC, the present study aims to characterize whole transcriptomic changes associated with the effect of CARD11 overexpression in CRC cell lines as well as the effect of CARD11 overexpression in colorectal adenoma and carcinoma patient samples. Here, CARD11 is linked to colorectal adenoma.