MMP9 and lung adenocarcinoma: When AKR1B10 is silenced in lung adenocarcinoma cells, it suppresses their extravasation through the BBB in vitro, ex vivo microfluidic chip, and in vivo models; moreover, AKR1B10 silencing induced the downregulation of metastatic cells’ expression of matrix metalloproteinase MMP-2 and MMP-9 [35].