The downregulation of B7-H6 expression in glioma stem-like cells deactivated the PI3K/AKT signaling pathway [36,45] and promoted cell proliferation, migration, invasion, and metastasis in glioma by decreasing matrix metalloproteinase (MMP)-2, MMP-9, Vimentin, N-cadherin, and Survivin levels and increasing E-cadherin and Bax levels [34]. Here, MMP9 is linked to central nervous system cancer.