In cases of LPS-induced endometritis, an elevation in levels of reactive oxygen species (ROS) may precipitate oxidative stress, leading to cellular apoptosis and the regulation of inflammatory responses through the activation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway and inhibition of nuclear factor erythroid 2-related factor 2 (Nrf2) translocation to the nucleus [16], which further causes apoptosis and regulates inflammatory changes via the activation of NF-κB signaling and blocking the translocation of Nrf2 to the nucleus [17,18]. The gene discussed is NFE2L2; the disease is endometritis.