This is an extremely complex locus, with two genes (MYOZ1 and SYNPO2L) regulated inversely by the AF risk haplotype, four transcript isoforms for one of these genes (SYNPO2L), two of which produce different protein isoforms (CHAP977 and CHAP753) and two of which produce lncRNAs. The gene discussed is MYOZ1; the disease is atrial fibrillation.