Given the important role of ALDH1B1 in ethanol metabolism, targeting ALDH1B1 strategies may also hold promise for improving cancer treatment outcomes, particularly in patients with high ethanol consumption, by targeting key metabolic (e.g., normalizing the NADH/NAD+ ratio and shifting cancer cell metabolism) and protective mechanisms (e.g., reducing cancer stem cell populations, chemoresistance and ethanol-induced inflammatory and immunosuppressive effects) in cancer cells [37,38,39]. Here, ALDH1B1 is linked to cancer.