CHGA and limb ischemia: Additionally, the C-terminal sequence of vasostatin II, CgA79–113, was reported to inhibit the vasoconstrictive effects of angiotensin II, whereas catestatin-induced proliferation, migration, and in-vitro angiogenesis in human venous endothelial cells and improved limb ischemia by inducing angiogenesis, vasculogenesis, and arteriogenesis.