CASP3 and cervical carcinoma: Furthermore, our Western blot analysis showed that the protein level of pro-caspase-3 decreased, but cleaved caspase-3 and cleaved PARP1 increased in MCPIP1-overexpressing HeLa and SiHa cells (Figure 1E,F), which further validated the pro-apoptotic role of MCPIP1 in cervical cancer cells.