PARP1 and neoplasm: Furthermore, Western blot analysis of excised HeLa tumor tissues demonstrated the overexpression of MCPIP1 in tumors treated with SLpMCPIP1 (+), and SLpMCPIP1 (+) further reduced XIAP but increased the expression of cleaved caspase-3 and cleaved PARP1 proteins compared with SLpEmpty (+) treatment (Supplementary Figure S9).