Variants in four genes (ROPN1, PRSS3, BPIFB1, and BCORL1) were detected in all individuals from Family 2, while four (TUBB2B, CAFAP54, PSG2, and SIRPB1) were exclusive of the MPT21 index case and her relative with cancer (MPT21.2). The gene discussed is BPIFB1; the disease is cancer.