TRIM54 and Alzheimer disease: The ubiquitin–proteasome system (UPS) and the autophagy lysosomal pathway (ALP) contribute to more than 80% of protein degradation [19], and we found that UPS markers such as Murf and Fbxo 32 were significantly downregulated in the skeletal muscle of AD mice (Figure 4A–D,I–K), as well as ALP-related factors At9a and LC3a (Figure 4E–H), while the treadmill exercise reversed this trend.