(7) Two transcription factors, Fosb and Egr1, as well as their corresponding target genes Srrm4, Socs1, Il1b, Fosb, and Egr1, were significantly downregulated in the AD mice compared to the wild-type mice, while these transcription factors and target genes were upregulated after the treadmill exercise. This evidence concerns the gene SRRM4 and Alzheimer disease.