SOCS3 and Alzheimer disease: Notably, six signaling pathways involved in osteoclast differentiation (genes Fosb, Il1b, Socs1, and Socs3), IL-17 signaling (genes Fosb and Il1b), AGE-RAGE signaling in diabetic complications (genes Egr1 and Il1b), African trypanosomiasis (gene Il1b), and TNF signaling (gene Il1b and Socs3); and growth hormone synthesis, secretion, and action (genes Socs1 and Socs3) were downregulated in the AD mice compared to the WT mice, while they were upregulated after the treadmill exercise.