PRKG1 and AIDS dementia complex: Meanwhile, compared to the ADC group, the enriched downregulated genes in the ADE group were mainly involved in the cAMP signaling pathway, calcium signaling pathway, cGM–PKG signaling pathway, amyotrophic lateral sclerosis, and neurodegeneration pathways in multiple diseases (Figure 7C), while the enriched upregulated genes were associated with osteoclast differentiation, TNF, Wnt, NOD-like receptor, and IL-17 signaling pathways (Figure 7D).