TNF and Alzheimer disease: The results of 20 enrichment bars indicate that compared to the WTC group, the enriched downregulated genes in the ADC group were mainly associated with the TNF signaling pathway; osteoclast differentiation; dopaminergic, cholinergic, and glutamatergic synapses; the IL-17 signaling pathway; and growth hormone synthesis and secretion (Figure 7A), which indicates deficiency in synaptic functions, immune functions, and cell growth in the AD mice skeletal muscle.