ADCY8 and dilated cardiomyopathy: Furthermore, five signaling pathways associated with dilated cardiomyopathy (genes Adcy8, Atp2a2, Myh7, Myl3, Ryr2, Tnnc1, and Tpm3); adrenergic signaling in cardiomyocytes (genes Adcy8, Atp2a2, Atp2b2, Myh7, Myl3, Ryr2, Tnnc1, and Tpm3); cardiac muscle contraction (genes Atp2a2, Myh7, Myl3, Ryr2, Tnnc1, and Tpm3); hypertrophic cardiomyopathy (genes Atp2a2, Myh7, Myl3, Ryr2, Tnnc1, and Tpm3); and cAMP signaling (genes Adcy8, Atp2a2, Atp2b2, Gria2, and Ryr2) were upregulated, while they were downregulated after the treadmill exercise.