The results of 20 enrichment bars indicate that compared to the WTC group, the enriched downregulated genes in the ADC group were mainly associated with the TNF signaling pathway; osteoclast differentiation; dopaminergic, cholinergic, and glutamatergic synapses; the IL-17 signaling pathway; and growth hormone synthesis and secretion (Figure 7A), which indicates deficiency in synaptic functions, immune functions, and cell growth in the AD mice skeletal muscle. This evidence concerns the gene GH1 and Alzheimer disease.