Physical activity led to the significant upregulation of ubiquitin-mediated proteolysis (genes Socs1 and Socs3), as well as signaling pathways involved in protein digestion and absorption (genes Col11a1 and Kcnj13) in the skeletal muscle of AD mice, suggesting the promotion of proteolysis, consistent with the qRT-PCR and protein immunoblotting results. The gene discussed is SOCS1; the disease is Alzheimer disease.