In addition, approximately 60% (23/38) of the protein–OD pairs showed negative causality, indicating that these proteins may play a protective role in the corresponding OD, such as protein-coding genes GSTM3 for senile cataract (odds ratio (OR) = 0.926, 95% confidence interval (CI) (0.898, 0.954), FDR.p = 3.59 × 10−6), IGFBP7 for AMD (OR = 0.878, 95%CI (0.825, 0.934), FDR.p = 3.12 × 10−4), EFEMP1 (OR = 0.992, 95%CI (0.988, 0.996), FDR.p = 2.51 × 10−4) for myopia, and SIRPG (OR = 1.181, 95%CI (1.089, 1.280), FDR.p = 4.81 × 10−4) for DR. This evidence concerns the gene SIRPG and age-related macular degeneration.