After correction for multiple testing, we identified two potential causal genes (Table S5), namely KHK associated with senile cataract (OR = 1.089, 95%CI (1.035–1.145), FDR.p = 1.44 × 10−3) and CFHR1 (OR = 3.049, 95%CI (2.636–3.527), FDR.p = 7.04 × 10−50). The gene discussed is KHK; the disease is senile cataract.