Among the 11 plasma-protein–OD pairs, 6 pairs (protein-coding genes GSTM3 for senile cataract, C3, IGFBP7 and PILRA for AMD, EFEMP1 for myopia, SIRPG for DR) have been identified in previous studies, while the other 5 pairs (protein-coding genes ECI1, LCT and NPTXR for glaucoma, WARS1 for AMD, SIGLEC14 for DR) are newly reported. The gene discussed is IGFBP7; the disease is age-related macular degeneration.