A total of 11 unique protein-coding genes posterior probability (PP) of H4 > 0.70 finally remained, including GSTM3 for senile cataract, WARS1, C3, IGFBP7, and PILRA for AMD, ECI1, LCT, and NPTXR for glaucoma, EFEMP1 for myopia, and SIRPG and SIGLEC14 for DR. The gene discussed is SIGLEC14; the disease is age-related macular degeneration.