By combining the key terms “TRPV1” OR “Transient receptor potential vanilloid 1” OR “β2AR” OR “β2-adrenergic receptor” AND “respiratory diseases” OR “asthma” OR “wheezing” OR “respiratory infections” OR “COPD” OR “cystic fibrosis” in a computerized search of PubMed, we provide a complete overview of the current literature, based on a critical evaluation without standardized methodologies or statistical analyses. The gene discussed is ADRB2; the disease is cystic fibrosis.