Cancer-related inflammation leads to the production of monocytes in the bone marrow through mediators such as IL-6, the granulocyte-macrophage colony stimulating factor (GM-CSF), or the granulocyte-colony stimulating factor (G-CSF) released by cancer cells, but splenic hematopoietic stem cells and progenitor cells are also involved in this process [78,79,80,81]. The gene discussed is CSF3; the disease is cancer.