Serum interleukin-34 (IL-34) is correlated with liver inflammation and fibrosis in patients with chronic hepatitis B. Interleukin-32 (IL-32) is crucial in local invasion or distant metastasis perhaps by inhibiting the activity of NK cells against HCC, and NK cells have a protective function against liver fibrosis; there are studies on the use of invariant natural killer T in therapies for HCC [153,154,155]. This evidence concerns the gene IL32 and chronic hepatitis B virus infection.