M2-TAMs are alternatively activated through IL-4, IL-10, IL-13, TGF-β, colony-stimulating factor 1 (CSF-1), or prostaglandin E2 (PGE2), and, differently than M1-TAMs, reveal immunosuppressive properties, promoting tumor growth, angiogenesis, and metastasis [82,84]. The gene discussed is TGFB1; the disease is neoplasm.