The pro-tumorigenic role of neutrophils results from the expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) and the tumor necrosis factor (TNF) in peri-tumoral tissues within HCC, enhancing the immunomodulatory effect of neutrophils and leading to the suppression of T lymphocytes [125,126]. Here, CSF2 is linked to hepatocellular carcinoma.