Manzi et al. (2016) revealed that the proliferation and migration of LSECs are regulated by galectin-1(Gal-1); Gal-1 is a β-galactoside binding protein that, through a glycosylation-dependent mechanism, plays a key role in vascular biology, and exhibits overexpression in the case of malignant tumors, affecting cell adhesion, and tumor-immune escape or tumor progression [71,72,73,74]. This evidence concerns the gene LGALS1 and cancer.