APOC1 and hepatocellular carcinoma: In a recent study, Hao et al. (2022), using single-cell RNA-sequencing, demonstrated that the apolipoprotein C1 (APOC1) gene exhibits overexpression in TAMs derived from HCC tissues, and further authors revealed that APOC1 inhibition entails the transformation of the TAMs from an M2 phenotype to an M1 phenotype through a ferroptosis pathway as indicated in the altered genes expression which is distinctive for ferroptosis.