Among CAFs releasing cytokines, CCL5 or CXCL11 exacerbate HCC malignancy and promote metastasis; further, proteins such as the hepatocyte growth factor (HGF) or follistatin-like protein 1 (FSTL-1) also reveal prometastatic abilities, while the blockage of the aforementioned factors improved HCC outcomes presented in the experimental models [90,93,94,95,96]. This evidence concerns the gene FSTL1 and hepatocellular carcinoma.