TNF and obesity due to melanocortin 4 receptor deficiency: When evaluating plasma inflammatory parameters, it was observed that TNF-α was significantly higher in females and males from the obesity 1 and obesity 2 groups (obesity 1: 16.39 (1.17) pg/mL/p = 0.0003, and obesity 2: 16.33 (0.79) pg/mL/p = 0.0004) than control group 1 (Figure 7A).