Col has an anti-obesity effect and alleviates lipogenesis through increasing acetyl-CoA carboxylase bioactivity, suppressing the expression of SREBP1/2, PPARγ, and sig1/2, enhancing the relative abundances of Dubosiella, Alistipes, and Alloprevotella; enriching the acetic acid contents; and inhibiting AMPK phosphorylation. Here, SREBF1 is linked to obesity due to melanocortin 4 receptor deficiency.