On the other hand, the recent findings of Silva et al. [85] show that 12 weeks of RT per se, i.e., without Vit-D supplementation, may have an anti-inflammatory effect, including a strong tendency to improve the IL-10/TNF-α ratio, in middle-aged and elderly patients with chronic obstructive pulmonary disease (COPD). This evidence concerns the gene TNF and chronic obstructive pulmonary disease.