Alterations that may be more typical late in the course of carcinogenesis in FTE or ovarian cancer cells such as activation/overexpression of CYP24A1 can potentially abrogate the cancer-preventive effects of vitamin D. It is intriguing that the inhibition of CYP24A1 may sensitize the FTE to cholecalciferol-induced cell death. The gene discussed is CYP24A1; the disease is cancer.