ITGAM and Parkinson disease: One study of 12-week-old toxin-induced Parkinsons disease models from the B6J background fed a 60% HFD for 21 weeks demonstrated a decrease in the interaction between CD11b-positive cells and blood vessels of the striatum, demonstrating that HFD-induced changes to the function of activated microglia may play a role in the pathogenesis of dopaminergic degeneration [64].