Given that vasopressin directly promotes renal cyst growth in ADPKD via the vasopressin type 2 receptor (V2R) [49], and given that the sole approved drug for ADPKD is a V2R antagonist [50], it seems clear that fructose consumption cannot possibly be beneficial for individuals with ADPKD but can only be detrimental. This evidence concerns the gene AVPR2 and autosomal dominant polycystic kidney disease.