However, in covariate sets 1 and 2, no significant correlation was found between the PRS and serum total cholesterol, TG, LDL, CRP, and HDL, as well as waist circumference, hypertension, and type 2 diabetes risk (p > 0.05), indicating that PRSs may only be significantly associated with gastric cancer, while metabolic markers such as cholesterol and triglycerides are affected by multiple factors such as genetics, diet, and lifestyle, and the complexity and diversity of these factors may make it difficult to simply summarize the relationship between metabolic markers and gastric cancer risk. The gene discussed is CRP; the disease is hypertensive disorder.