Furthermore, it has been shown that hyperglycaemia increases the migration speed of both BC cell lines via the reduction of cortical F-actin expression, chromatin condensation and the upregulation of both nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and mesenchymal markers such as vimentin and E-cadherin [50]. This evidence concerns the gene NFKB1 and breast cancer.