In agreement with this, it has been reported that leptin in BC cells can induce the activation of multiple oncogenic pathways, including JAK/STAT3, ERK1/2 and PI3K, whose cascade culminates with the induction of genes involved in cell proliferation like cyclin D1 and c-myc or the activation of AKT/SREBP-2 pathway, respectively [109]. This evidence concerns the gene LEP and breast cancer.