In a study of insulin-resistant (n = 28) and insulin-sensitive (n = 28) women with overweight or moderate obesity, there was a clear between-group difference in FFA levels during stage 1 of the IST caused by an insufficient suppression of lipolysis in the insulin resistant group, and the authors claim the stage 1 FFA to be more informative than stage 1 SSPG [22]. The gene discussed is INS; the disease is obesity disorder.