Indeed, a study carried out by Alvisi and colleagues [26] on a larger cohort of CCA patients (n = 147) demonstrated that a dominant presence of CD4+ Treg cells overexpressing MEOX1 in the tumor infiltrate was associated with a poorer prognosis and shorter overall survival, as compared to individuals presenting lower MEOX1 expression. This evidence concerns the gene MEOX1 and cholangiocarcinoma.