An experimental study showed that mice with heterozygous protein C deficiency had worse outcomes, increased fibrin deposition in the lungs, kidneys, liver, and higher levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and IL-1β after an intraperitoneal injection of Escherichia coli endotoxin [170]. This evidence concerns the gene TNF and hyperinsulinemic hypoglycemia, familial, 4.