DBH and hypertensive disorder: On the premise of the importance of DβH in managing HTN, four major categories of DβH inhibitors have been identified and tested to date: (1) copper chelator-based inhibitors: disulfiram and fusaric acid [147,148]; (2) thiocarbonyl encompassing heterocyclics as inhibitors: imidazolidine, tetrazole, and benzimidazole derivatives as the top alternative; (3) mechanism-based inhibitors: 2-thiophen-2-ylamine was the most effective inhibitor from this class; and (4) imidazole 2-thione-based inhibitors: nepicastat, etamicastat, and zamicastat [149].