The nucleotide-binding domain, leucine-rich–containing family, pyrin domain-containing-3 (NLRP3) inflammasome is a key component of the innate immune system activating several pro-inflammatory downstream pathways involved in cardiovascular disease and comorbidities associated with HFpEF including obesity, diabetes mellitus, hypertension, and chronic obstructive pulmonary disease [38]. The gene discussed is NLRP3; the disease is cardiovascular disorder.