Considering the role of specific IgE SEs in severe asthma, we aimed to determine whether the presence of SEs is associated with inflammatory cells in the airways obtained either by sputum and/or by bronchoalveolar lavage (BAL), features of airway remodeling obtained by bronchial biopsies, and other different parameters relating to asthma assessment and severity, such as lung function, atopic status, and ACT score. The gene discussed is IGHE; the disease is asthma.