Eventually, antibodies targeting peptide structures of the node and paranode including contactin1 (CNTN1), contactin-associated protein 1 (Caspr1), and different neurofascin (NF) isoforms (NF155, NF186/140) were identified in subsets of patients presenting clinical features reminiscent of Guillain–Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) [3,4,5]. Here, CNTN1 is linked to chronic inflammatory demyelinating polyradiculoneuropathy.