Out of the 30 circulating proteins identified in our study, only CD63, FKBP5, N-Alpha-Acetyltransferase 10, NatA catalytic subunit (NAA10), PTPN1, and TNF receptor superfamily member 12A (TNFRSF12A) exhibited differential expression between the hypothalamic tissue of subjects with PWS and with non-syndromic obesity in the Bochulova’s study (Figure S1A and Table 4). Here, CD63 is linked to obesity due to melanocortin 4 receptor deficiency.