Interestingly, correlation analysis in PWS significantly associated Ribokinase (RBKS), KYNU, Macrophage Scavenger Receptor 1 (MSR1), and SMPD1 with metabolic and liver dysfunction markers, such as transaminases, triglycerides, glycemia, and glycated hemoglobin (Figure 4A). Here, SMPD1 is linked to digestive system neoplasm.