NMNAT1 and Prader-Willi syndrome: This elucidates the enrichment observed in pathways related to ‘NAD metabolism’, ‘Tryptophan catabolism leading to NAD production’, and ‘NAD biosynthesis II’, influenced by other circulating proteins reduced in PWS, such as KYNU, an enzyme involved in Tryptophan metabolism [69,70] and NMNAT1, and denylyl transferase [71], both contributing to NAD metabolism.