Patients with definite HFpEF were older (p < 0.001) and more likely to have a history of renal failure (p = 0043), a higher CHA2DS2-VASc score (p < 0.001), and higher NTproBNP levels in sinus rhythm (p < 0.001) and AF (p = 0.001). This evidence concerns the gene NPPB and atrial fibrillation.