CST3 and Abnormal renal physiology: The authors randomized 360 hospitalized participants with acute HF and renal dysfunction (estimated GFR of 15–60 mL/min/1.73m2) in either a low-dose dopamine group of 2 μg/kg/min or a low-dose nesiritide group of 0.005 μg/kg/min, added to diuretic therapy, and compared them to the placebo in order to evaluate the decongestion endpoint assessed by the 72 h cumulative urine volume and the renal function endpoint assessed by the 72 h change in serum cystatin-C.